Senni studied Musicology at the University of Bologna. His third LP, Quantum Jelly, appearing on the independent record label Editions Mego, was received with unanimous acclaim; including 10th on the Boomkat TOP100 of 2012, 34th on Fact TOP50 releases of 2012, and 7th on DEBUG November 2012 Chart. The work is a record deeply influenced by Senni’s love of 90s trance/hard-trance music and a growing interest of the musical structures and sound archetypes of this genre. Senni works the most obvious characteristics from such music – spoon-fed with super-saws, build-ups of several minutes, and over-the-top instant gratification melodies – into his own background in experimental, noise, and abstract computer music. For instance, he’ll create tracks with just one simple idea, and force it into a "non-build-up", a sonic spiral of repetitive and percussive arpeggiated melodies, or, again using the idea of the "build-up" as a starting point, he’ll make a non-uplifting track that implicitly preserves its emotional tension and drama.

As founder of Presto!?, Senni has released albums by a number of internationally acclaimed artists including Florian Hecker, DJ Stingray, Marcus Schmiclker, Carl Michael von Hausswolff, John Wiese, Werner Dafeldecker, Lawrence English, Alberto de Campo, Greg Davis, and more. Throughout his global touring Senni has opened for Peter Rehberg & Stephen O’ Malley (KTL), Cut Hands (William Bennett, Whitehouse), John Wiese, EVOL, Dave Phillips, and others.

Senni also composes music for cinema. His soundtrack for the award-winning movie, Da Vinci, was screened at the 55th Venice Biennale. He has also collaborated with the theatre companies Orthographe and Pathosformel.

Lorenzo Senni is supported through the SHAPE platform, which is supported by the Creative Europe Programme of the European Union.